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Acronyms and initialisms are both types of abbreviations that are formed from the first letters of a group of words, without spaces (and usually without periods).
Although they are formed the same way, acronyms and initialisms are pronounced differently.
An acronym is pronounced as a word:
In an intialism, each letter is pronounced separately or sounded out:
As a general rule, use upper-case letters for acronyms or initialisms in their entirety, even if some of the component words or their parts are not normally capitalized (unless the organization concerned prefers lower case):
One exception to the above rule occurs in the case of common-noun acronyms treated as full-fledged words; these are written entirely in lower case without periods:
A second exception involves acronyms of company names that are formed from more than the initial letters of the words they represent. Usually, in that case, only the first letter of the acronym is capitalized:
When using acronyms or initialisms that include an abbreviation for number, do not repeat the word number after the abbreviation. Either write the expression out in full, or use the abbreviated form on its own.
The rules concerning the use of an article before the abbreviation are different for acronyms and initialisms.
Usually, an article is not used before an acronym:
However, if the acronym is used as a modifier, it may be preceded by the definite or indefinite article:
When the indefinite article is used before an acronym, the choice of form (a or an) depends on pronunciation, not on spelling; in other words, use a if the acronym begins with a consonant sound, and an if it begins with a vowel sound:
The definite article is used before many initialisms (including those representing the name of an organization):
But the definite article is omitted before an initialism representing a substance, method or condition:
In the case of the indefinite article, since initialisms are abbreviations pronounced letter by letter, you must go by the pronunciation of the first letter when choosing whether to use a or an.
If the first letter begins with a consonant sound when pronounced, then choose the article a:
But if the first letter in the initialism starts with a vowel sound when pronounced, then choose the article an:
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