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Most dictionaries list irregardless as non-standard English and advise against its use in speech and writing. It is an illogical formation, since it contains a double negative: the negative prefix ir- (meaning "not"), combined with the negative suffix -less.
The correct word is regardless. The word irrespective is also correct and may replace regardless in the expression regardless of.
Use regardless as an adverb meaning "anyway" or "nonetheless":
Use regardless of or irrespective of as a preposition meaning "in spite of" or "without regard to":
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